Location: US-221 and King St, Boone Reassurance shield as US-221 splits from US-421 and NC-105 begins.  Location: US-221 and Horn Ave, Boone Northbound US-421 trucks are also advised to use this street. Location: US-221 and Blowing Rock Rd, Boone A few blocks later, we’ll approach US-321. Location: US-221 and Blowing Rock Rd, Boone At the … Continue reading U.S. Route 221, US-421/NC-194/NC-105 to US-321/NC-105